Yes, I think at least the main inhabitants of Collinwood would definitely have to get the POP treatment. They could also segment these out into different lines. Like releasing the members of the Collins family first, then perhaps a villains line (Nicholas, Angelique, etc), a townsfolk line (Sam, Maggie, Stokes) and more.
It would be really interesting to get some of the more supernatural characters out there, like the ghost of Sam Evans MB mentioned. Or what about the ghost of Jeremiah, with his bandaged wrapped face? Or Josette in her wedding gown with the eye on her cheek?!