This is too funny - we both had the same idea for Julia (Susan Sarandon) and Carolyn (Sarah Michelle Gellar). Although technically Carolyn was only 18 when DS debuted, but Nancy Barrett had to be older than that.
I like TVGuide.com's idea of using Angelina Jolie as Angelique.
I thought that was an interesting choice. And for those who may have missed that posting, check here: (URL). Be sure to check out the comments too because a few are interesting.
Johnny Depp Barnabas CollinsJulianne Moore as Dr Jullia HoffmanJoan Allen as Elizabeth StoddardAaron Eckhart as Roger CollinsMatthew McConaughey as Burke DevlinLindsey Lohan as AngeliqueHillary Duff as Vitoria WintersHeath Leger as Joe HaskellScarlet Johansen as Carolyn StoddardShia LaBeouf as Willie LoomisEvan Rachel Wood as Maggie EvansJohn Goodman as Sam Evans
Cate Blanchett as AngeliqueKate Hudson as Carolynand I'm tossing between Helen Mirren, Diane Keaton, and Judi Dench as Elizabeth, though I'm leaning heavily towards Judi Dench.