I think that teen girls are inevitably going to be part of the target audience for DS. I'm not as sure about 10-13 year olds- certainly Johnny himself has many fans that age from the Pirates films, but I think that for DS, that's a little young. I would guess that the *minimum* rating they'll go for is a PG-13, and I wouldn't be too surprised if they decide to go for an R, as they did with Sweeney Todd. (Not that I am in favor of a slasher-type film, but I don't want them to be afraid to make it dark). Didn't I hear that a lot of *moms* like Twilight, though? The moms will definitely be all over a Depp DS film, especially if they're old enough to remember the original. But I agree with MB and Taeylor that I hope the target audience is going to be much broader than this.
Regarding the male audience, while a lot of the die-hard Depp fans are female, I think that males respect him, as well, and I think it won't hurt that his upcoming films Public Enemies and The Rum Diary will help to keep the male fanbase interested in what else Depp will be up to, including DS.
I agree, Jimbo, that Vicki should look 25 at the *most*. College educated, perhaps with a master's in education, but still young and just starting a career. I think Joanna Going was perfect, at the time. I just checked IMDb, and she was born in '63, so was 27 or 28 for DS- that was pretty good.