If Russ Meyer made HODS, Marie Wallace would've been cast as Maggie, and Nancy Barrett would still be Carolyn, as both women were, in Meyer's logic, "voluptuous", and like Howard Hughes, he never met a bosom he didn't like. Of course, Joan Bennett would be replaced by Jane Russell!
As to "VD", Grayson would steal the show as Helen Lawson, especially in the powder-room scene! I'd prefer Jerry Lacy as Tony Polar with Marie Wallace as Miriam, Thayer David as Henry Bellamy, Clarice Blackburn as Miss Steinberg, and Louis Edmonds as Ted Casablanca!
BTW, there are already two DS actors in the actual 1967 film: Robert Viharo, who played the handsome theatrical director in the rehersal hall scenes at the start of the film and reappears as Helen's escort at the party just before the 'powder room' sequence, appeared in DS' second episode. He was the young man (along with Alan Feinstein) who danced with Carolyn at The Blue Whale. Also, Judith Lowry who played Anne's Aunt Amy was on DS as a hand double for the aged Cassandra after Sam's painting aged her to 200 years!