I like the comment about Dr Hoffman opting for a smaller, less prestigous shall we say, hospital where she probably was given more leeway to do the type of research that she wanted. Dave did comment that she was brilliant in research. The type of research that she was doing probably didn't make big waves and was only of interest to a small group of researchers. I really think that they were very good friends over the years and then she felt like she betrayed that friendship when Barnabas killed him.