I'm still of the mind that I wouldn't be at all surprised if Marvel's The Avengers repeats at #1 for the weekend DS opens, which would mean the highest DS could place would be at #2.
As for What To Expect When You're Expecting, it's going to be really interesting to see how that does. In general comedies that are strongly female driven have not been doing well - Bridesmaids being an exception. And Cameron Diaz' movies have not been drawing like they once did. It may all come down to the sweet vs. raunch factor in the movie. I know nothing about the movie's plot. However, if it's more raunchy than sweet, the movie could potentially do well. But if it's more or all on the sweet side, it's anyone guess how it will do because a lot of those types of films have been practically DOA lately...
Also, a lot is going to depend on how DS is marketed, and in this case, how it's marketed to women. The interesting thing so far is that on the most anticipated lists that we've seen WTEWYE has been nowhere to be seen...
146 days 10 hours 19 minutes 11 seconds until the day the Depp/Burton Dark Shadows is released(ET)!!