I was very excited to hear this news the other day. I know a lot of fans are die-hard for the original and are very skeptical when it comes to any sort of reboot/remake/continuation. And they should be. But I'm hopeful. At a bare minimum, even if this doesn't work out, the fact that DS can still pop in in mainstream pop culture after 50 years and potentially generate new interest just speaks to the power of this brand (and those working behind it).
I'm also encouraged by Perry's comments regarding the original and his love for it. I think he hit the nail on the head when quoting Julia Hoffman's comment about the family history not being particularly accurate. This is a great approach to take that could allow for them to rewrite some of the history, the bumps in the road, and mine some further story out of this franchise. It also could lend itself to the inclusion of some of the original actors as their original characters when done correctly.
I also think that the CW is looking for somewhere to drive fans of Supernatural, a long running and successful show for them, because that is ending with this newest season. So if things work out correctly, perhaps DS could slide in and absorb some of their fanbase.