I too think as Cassandra, Angelique was definitely at her meanest. Let's look at her track record:
(Spoilers):
She started the dream curse, scaring the pants off of many people (Maggie, Jeff, Lang, Julia, Mrs Johnson, David, Willie, Carolyn, Sam, Vicki).
She marries Roger but totally ignores him.
She enslaved Tony Peterson.
She made David mute.
She blinded Sam, then made him have the dream, then rose his spirit up from the grave after he died.
She cursed Elizabeth with a fear of being buried alive, then bewitched her into think she was Naomi.
She tried to kill Adam.
Sheesh, was there anyone she wasn't cruel to as Cassandra?